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DoseCalc OnLine
spacer Guide To Oncology Regimens

DISEASE: Lung: Non Small Cell

Select a REGIMEN:

CAMP
CAP
CBDCA+VP-16
CDDP + VP-16
FED
MVP
NVB[Navelbine(R)]-30
NVB[Navelbine(R)]-15
NVB-30+CDDP
NVB-15+CDDP
PVP-16
VIP(ICE)-2





DISEASE: Lung: Non Small Cell

REGIMEN: CAMP

    CYCLOPHOSPHAMIDE [CTX] 300 mg/m2 IV...D1,8

    DOXORUBICIN [DOX] 20 mg/m2 IV...D1,8
    Caution: Monitor cumulative dose (cardiac toxicity)

    METHOTREXATE [MTX] 15 mg/m2 IV...D1,8

    PROCARBAZINE [PCB] 100 mg/m2 per day PO...D1-10

CYCLE: 28 days
REFER: Bitran JD, et al: CANCER TREAT REP 1976; 60:1225-1230.




DISEASE: Lung: Non Small Cell

REGIMEN: CAP

    CYCLOPHOSPHAMIDE [CTX] 400 mg/m2 IV...D1

    DOXORUBICIN [DOX] 40 mg/m2 IV...D1
    Caution: Monitor cumulative dose (cardiac toxicity)

    CISPLATIN [CDDP] 60 mg/m2 IV...D1

CYCLE: 28 days
REFER: Eagan RT, et al: CANCER TREAT REP 1979; 63:1589-1591.




DISEASE: Lung: Non Small Cell

REGIMEN: CBDCA+VP-16

    CARBOPLATIN [CBDCA] 325 mg/m2 IV...D1

    ETOPOSIDE [VP-16] 100 mg/m2 per day IV...D1-3

CYCLE: 28 days
REFER: Klastersky JP: J CLIN ONCOL 1990; 8:1556-1562.




DISEASE: Lung: Non Small Cell

REGIMEN: CDDP + VP-16

    CISPLATIN [CDDP] 60 mg/m2 IV...D1

    ETOPOSIDE [VP-16] 120 mg/m2 IV...D4,6,8 "or D3,5,7"

CYCLE: 21-28 days
REFER: Longeval E, et al: CANCER 1982; 50:2751-2756.




DISEASE: Lung: Non Small Cell

REGIMEN: FED

    CISPLATIN [CDDP] 100 mg/m2 IV/over 3-4 hrs...D1

    ETOPOSIDE [VP-16] 80 mg/m2 per day IV...D2,3,4

    FLUOROURACIL [5-FU] 960 mg/m2 per day x 3 CIV...D2,3,4
    (2880 mg/m2 total)

CYCLE: 3 weeks
REFER: Sridhar KS, et al: SEMIN IN SURG ONCOL 1993; 9:114-119.




DISEASE: Lung: Non Small Cell

REGIMEN: MVP

    MITOMYCIN C [MITC] 10 mg/m2 I...D1
    Caution: Monitor cumulative dose (marrow toxicity, hemolytic uremic syndrome)

    VINBLASTINE [VLB] 6 mg/m2 IV...D1

    CISPLATIN [CDDP] 40 mg/m2 IV...D1

CYCLE: 21 days
REFER: Bonomi PD, et al: J CLIN ONCOL 1989; 7:1602-1613.




DISEASE: Lung: Non Small Cell

REGIMEN: NVB[Navelbine(R)]-30

    VINORELBINE [NVB] 30 mg/m2 IV...weekly
    Use 30mg/m2 when granulocytes >= 1500; down dose to 15mg/m2 when granulocytes 1000-1499.

CYCLE: None
REFER: LeChevalier T, et al: J CLIN ONCOL 1994; 12:360-367.




DISEASE: Lung: Non Small Cell

REGIMEN: NVB[Navelbine(R)]-15

    VINORELBINE [NVB] 15 mg/m2 IV...weekly
    Use 15mg/m2 when granulocytes 1000-1499; no NVB when granulocytes < 1000.

CYCLE: None
REFER: LeChevalier T, et al: J CLIN ONCOL 1994; 12:360-367..




DISEASE: Lung: Non Small Cell

REGIMEN: NVB-30+CDDP

    VINORELBINE [NVB] 30 mg/m2 IV...weekly
    Use 30mg/m2 when granulocytes >= 1500; down dose to 15mg/m2 when granulocytes 1000-1499.

    CISPLATIN [CDDP] 120 mg/m2 IV...D1,29 then q6wks

CYCLE: None
REFER: LeChevalier T, et al: J CLIN ONCOL 1994; 12:360-367..




DISEASE: Lung: Non Small Cell

REGIMEN: NVB-15+CDDP

    VINORELBINE [NVB] 15 mg/m2 IV...weekly
    Use 15mg/m2 when granulocytes 1000-1499; no NVB when granulocytes < 1000.

    CISPLATIN [CDDP] 120 mg/m2 IV...D1,29 then q6wks

CYCLE: None
REFER: LeChevalier T, et al: J CLIN ONCOL 1994; 12:360-367..




DISEASE: Lung: Non Small Cell

REGIMEN: PVP-16

    CISPLATIN [CDDP] 60 - 120 mg/m2 IV...D1

    ETOPOSIDE [VP-16] 50 - 120 mg/m2 per day IV...D1-3

CYCLE: 21-28 days
REFER: Klastersky J: SEMIN IN ONCOL 1986; 13(Suppl 3):104-114.




DISEASE: Lung: Non Small Cell

REGIMEN: VIP(ICE)-2

    IFOSFAMIDE [IFF] 1 - 1.2 g/m2 per day IV...D1-3
    with MESNA

    CISPLATIN [CDDP] 100 mg/m2 IV...D1,8

    ETOPOSIDE [VP-16] 60 - 75 mg/m2 per day IV...D1-3

CYCLE: 28 days
REFER: Perez EA, et al: PROC ASCO 1992; 11:314.




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