DISEASE: Lymphoma: Non Hodgkin's

Select a REGIMEN:

CHOP
CHOP-BLEO
COMLA
COP
CVP-1
DHAP
ESAP
MACOP-B
MIV
m-BACOD
PROMACE-CYTABOM
VACOP-B

REGIMEN: CHOP

CYCLOPHOSPHAMIDE [CTX] 750 mg/m2 IV... D1

DOXORUBICIN [DOX] 50 mg/m2 IV... D1
Caution: Monitor cumulative dose (cardiac toxicity)

VINCRISTINE [VCR] 1.4 mg/m2 IV... D1
Maximum dose is 2 mg

PREDNISONE [Pred] 100 mg per day PO... D1-5

CYCLE: 21 days
REFER: Skeel RT: Handbook of Cancer Chemotherapy, 3rd Ed. Little, Brown & Co. 1991; 343.

REGIMEN: CHOP-BLEO

CYCLOPHOSPHAMIDE [CTX] 750 mg/m2 IV... D1

DOXORUBICIN [DOX] 50 mg/m2 IV... D1
Caution: Monitor cumulative dose (cardiac toxicity)

VINCRISTINE [VCR] 2 mg IV... D1,5
Maximum dose is 2 mg

PREDNISONE [Pred] 100 mg per day PO... D1-5

BLEOMYCIN [BLEO] 15 units per day IV... D1-5
Caution: Monitor cumulative dose (pulmonary toxicity)

CYCLE: 14 or 21 days
REFER: Rodriguez V, et al: BLOOD 1977; 49:325-333.

REGIMEN: COMLA

CYCLOPHOSPHAMIDE [CTX] 1500 mg/m2 IV... D1

VINCRISTINE [VCR] 1.4 mg/m2 IV... D1,8,15
Maximum dose is 2 mg

METHOTREXATE [MTX] 120 mg/m2 IV... D22,29,36,43,50,57,64,71

LEUCOVORIN [Leu] 25 mg/m2 PO... D23,30,37,44,51,58,65,72
q6h x 4 doses beginning 24 hr post MTX

CYTARABINE [ARA-C] 300 mg/m2 IV... D22,29,36,43,50,57,64,71

CYCLE: 91 days
REFER: Gaynor ER, et al: J CLIN ONCOL 1985; 3:1596-1604.

REGIMEN: COP

CYCLOPHOSPHAMIDE [CTX] 400 - 800 mg/m2 IV... D1

VINCRISTINE [VCR] 2 mg IV... D1
Maximum dose is 2 mg

PREDNISONE [Pred] 60 mg/m2 per day PO... D1-5
Followed by tapering dose 40,20,10 mg/day

CYCLE: 14 days
REFER: Luce JK, et al: CANCER 1971; 28:306-317.

REGIMEN: CVP-1

CYCLOPHOSPHAMIDE [CTX] 400 mg/m2 per day PO... D1-5

VINCRISTINE [VCR] 1.4 mg/m2 IV... D1
Maximum dose is 2 mg

PREDNISONE [Pred] 100 mg/m2 per day PO... D1-5

CYCLE: 21 days
REFER: Bagley CM, et al: ANN INTERN MED 1972; 76:227-234.

REGIMEN: DHAP

CISPLATIN [CDDP] 100 mg/m2 CIV over 24 hrs... D1

CYTARABINE [ARA-C] 2 g/m2 IV over 3 hrs... D2
After Cisplatin repeat dose 12 hrs later for total dose of 4 g/m2

DEXAMETHASONE [DEX] 40 mg per day PO or IV... D1-4
For 4 days

CYCLE: 3-4 weeks
REFER: Velasquez WS, et al: BLOOD 1988; 71:117-122.

REGIMEN: ESAP

METHYLPREDNISOLONE[SOL] 500 mg per day IV... D1-4

ETOPOSIDE [VP-16] 40 mg/m2 per day IV... D1-4

CYTARABINE [ARA-C] 2 g/m2 IV... D5
Over 2 hr, after completion of Cisplatin

CISPLATIN [CDDP] 25 mg/m2 per day x 4 CIV... D1-4
(Total Dose 100 mg)

CYCLE: As tolerated
REFER: Velasquez W, et al: PROC ASCO 1989; 8:256.

REGIMEN: MACOP-B

METHOTREXATE [MTX] 400 mg/m2 IV... weeks 2,6,10

LEUCOVORIN [Leu] 15 mg PO
q 6 hr x 6 doses, starting 24hr after MTX

DOXORUBICIN [DOX] 50 mg/m2 IV... weeks 1,3,5,7,9,11
Caution: Monitor cumulative dose (cardiac toxicity)

CYCLOPHOSPHAMIDE [CTX] 350 mg/m2 IV... weeks 1,3,5,7,9,11

VINCRISTINE [VCR] 1.4 mg/m2 IV... weeks 2,4,6,8,10,12
Max dose 2mg

BLEOMYCIN [BLEO] 10 units/m2 IV... weeks 4,8,12
Caution: Monitor cumulative dose (pulmonary toxicity)

PREDNISONE [Pred] 75 mg per day PO
Tapered over last 15 days

CYCLE: None
REFER: Connors JM, et al (eds). Update on Treatment for Diffuse Large Cell Lymphoma. Wiley & Sons 1986; 37-43.

REGIMEN: MIV

MITOXANTRONE [DHAD] 10 mg/m2 IV... D1
Caution: Monitor cumulative dose (cardiac toxicity)

IFOSFAMIDE [IFF] 1500 mg/m2 per day IV... D1-3
With MESNA

ETOPOSIDE [VP-16] 150 mg/m2 per day IV... D1-3

CYCLE: 21 days
REFER: Herbrecht R, et al: PROC ASCO 1991; 10:278.

REGIMEN: m-BACOD

METHOTREXATE [MTX] 200 mg/m2 IV... D8,15

LEUCOVORIN [Leu] 10 mg/m2 PO... D9,16
q6h x 8 doses starting 24h after MTX

BLEOMYCIN [BLEO] 4 units/m2 IV... D1
Caution: Monitor cumulative dose (pulmonary toxicity)

DOXORUBICIN [DOX] 45 mg/m2 IV... D1
Caution: Monitor cumulative dose (cardiac toxicity)

CYCLOPHOSPHAMIDE [CTX] 600 mg/m2 IV... D1

VINCRISTINE [VCR] 1 mg/m2 IV... D1
Maximum dose is 2 mg

DEXAMETHASONE [DEX] 6 mg/m2 per day PO... D1-5

CYCLE: 3 Wks.
REFER: Shipp MA, et al: ANN INTERN MED 1986; 104:757-765.

REGIMEN: PROMACE-CYTABOM

PREDNISONE [Pred] 60 mg/m2 per day PO... D1-14

DOXORUBICIN [DOX] 25 mg/m2 IV... D1
Caution: Monitor cumulative dose (cardiac toxicity)

CYCLOPHOSPHAMIDE [CTX] 650 mg/m2 IV... D1

ETOPOSIDE [VP-16] 120 mg/m2 IV... D1

CYTARABINE [ARA-C] 300 mg/m2 IV... D8

BLEOMYCIN [BLEO] 5 units/m2 IV... D8
Caution: Monitor cumulative dose (pulmonary toxicity)

VINCRISTINE [VCR] 1.4 mg/m2 IV... D8
Maximum dose is 2 mg

METHOTREXATE [MTX] 120 mg/m2 IV... D8

LEUCOVORIN [Leu] 25 mg PO... D9
q6h x 4 doses starting 24 hrs after MTX

CYCLE: 21 days, next cycle begins on D22
REFER: Fisher RI, et al: PROC ASCO 1984; 242. Abstract.

REGIMEN: VACOP-B

ETOPOSIDE [VP-16] 50 mg/m2 IV... D1
And 100 mg/m2 per day PO D2,3 of week 3,7,11

DOXORUBICIN [DOX] 50 mg/m2 IV... weeks 1,3,5,7,9,11
Caution: Monitor cumulative dose (cardiac toxicity)

CYCLOPHOSPHAMIDE [CTX] 350 mg/m2 IV... weeks 1,5,9

VINCRISTINE [VCR] 1.2 mg/m2 IV... weeks 2,4,6,8,10,12
No maximum vincristine dose

PREDNISONE [Pred] 45 mg/m2 PO... q Dx1 week, then q OD x 11 wks

BLEOMYCIN [BLEO] 10 units/m2 IV... weeks 2,4,6,8,10,12
Caution: Monitor cumulative dose (pulmonary toxicity)

CYCLE: None
REFER: Connors JM, et al: PROC ASCO 1990; 9:254.

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