DISEASE: Multiple Myeloma

Select a REGIMEN:

DEXA
MP1
MP2
MP3
VAD

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DISEASE: Multiple Myeloma

REGIMEN: DEXA

DEXAMETHASONE [DEX] 40 mg per day PO... D1-4,9-12,17-20

CYCLE: 36 days
REFER: Alexanian R: ANN INTERN MED 1986; 105:8-11.

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DISEASE: Multiple Myeloma

REGIMEN: MP1

MELPHALAN [L-Pam] .15 mg/kg per day PO... D1-7

PREDNISONE [Pred] 20 mg TID PO... D1-7

CYCLE: 6 weeks
REFER: Kyle RA, Greipp PA: CRC CRIT REV ONCOL/HEMATOL 1988; 8:93-152.

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DISEASE: Multiple Myeloma

REGIMEN: MP 2

MELPHALAN [L-Pam] .25 mg/kg per day PO... D1-4

PREDNISONE [Pred] 2 mg/kg per day PO... D1-4

CYCLE: 6 weeks
REFER: Alkeran (R) (melphalan) Tablets, Burroughs Wellcome Co, full prescribing info in PHYSICIANS DESK REFERENCE 49th Ed. Montvale,NJ; 1995;746.

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DISEASE: Multiple Myeloma

REGIMEN: MP 3

MELPHALAN [L-Pam] 16 mg/m2 per day IV
Every 2 weeks for 4 doses, then every 4 weeks

PREDNISONE [Pred] .8 mg/kg per day PO... D1-14
Maximum dose is 100 mg/day

PREDNISONE [Pred] .4 mg/kg per day PO... D15-28
Maximum dose is 100 mg/day

PREDNISONE [Pred] .2 mg/kg per day PO... D29-42
Maximum dose is 100 mg/day

CYCLE: None
REFER: Cooper MR, et al: J CLIN ONCOL 1986; 4(9):1331 - 1339.

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DISEASE: Multiple Myeloma

REGIMEN: VAD

VINCRISTINE [VCR] .4 mg per day x 4 CIV... D1-4
Maximum dose is 2 mg

DOXORUBICIN [DOX] 9 mg/m2 per day x 4 CIV... D1-4
Caution: Monitor cumulative dose (cardiac toxicity)

DEXAMETHASONE [DEX] 40 mg per day PO... D1-4,9-12,17-20

CYCLE: 28 days
REFER: Barlogie B, et al: NEJM 1984; 310:1353-1356.

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