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DoseCalc OnLine
spacer Guide To Oncology Regimens


DISEASE: Head and Neck

Select a REGIMEN:

CF
COB
MBC
METHOTREXATE
PFL





DISEASE: Head and Neck

REGIMEN: CF

    CISPLATIN [CDDP] 100 mg/m2 IV...D1

    FLUOROURACIL [5-FU] 1000 mg/m2 per day x 4 CIV...D1-4
    (4000 mg/m2 total)

CYCLE: 21 days
REFER: Kish JA, et al: CANCER 1985; 56:2740-2744.




DISEASE: Head and Neck

REGIMEN: COB

    CISPLATIN [CDDP] 100 mg/m2 IV...D1

    VINCRISTINE [VCR] 1 mg IV...D2,5
    Maximum dose is 2 mg

    BLEOMYCIN [BLEO] 30 units per day x 4 CIV...D2-5
    Caution: Monitor cumulative dose (pulmonary toxicity)

CYCLE: 21 days
REFER: Skeel RT: Handbook of Cancer Chemotherapy, 3rd Ed. Little, Brown & Co. 1991; 152.




DISEASE: Head and Neck

REGIMEN: MBC

    METHOTREXATE [MTX] 40 mg/m2 IM or IV...D1,15

    BLEOMYCIN [BLEO] 10 units IM or IV...D1,8,15
    Caution: Monitor cumulative dose (pulmonary toxicity)

    CISPLATIN [CDDP] 50 mg/m2 IV...D4

CYCLE: 21 days
REFER: Skeel RT: Handbook of Cancer Chemotherapy, 3rd Ed. Little, Brown & Co. 1991; 153.




DISEASE: Head and Neck

REGIMEN: METHOTREXATE

    METHOTREXATE [MTX] 40 - 60 mg/m2 IV...weekly

CYCLE: None
REFER: Skeel RT: Handbook of Cancer Chemotherapy, 3rd Ed. Little, Brown & Co. 1991; 145-146.




DISEASE: Head and Neck

REGIMEN: PFL

    CISPLATIN [CDDP] 25 mg/m2 per day x 5 CIV...D1-5
    (Total Dose 125 mg/m2)

    FLUOROURACIL [5-FU] 800 mg/m2 per day x 5 CIV...D2-6
    (Total Dose 4000 mg/m2)

    LEUCOVORIN [Leu] 500 mg/m2 per day x 6 CIV...D1-6
    (Total Dose 3000 mg/m2)

CYCLE: 28 days
REFER: Dreyfuss AI, et al: ANN INTERN MED 1990; 112:167-172.




Glaxo Wellcome

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