DISEASE: Bladder

Select a REGIMEN:

BCG (THERACYS)
CISCA
CMV
MITOMYCIN
MVAC

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DISEASE: Bladder

REGIMEN: BCG (THERACYS)

BCG [BCG] 81 mg Intravesical...Weeks 1-6
q wk x 6 (induction)

CYCLE: Intravesical q wk x 6
REFER: Theracys (R) (BCG live intravesical) Connaught Labs, full prescribing info in PHYSICIANS DESK REFERENCE 49th Ed. Montvale,NJ; 1995;924.

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DISEASE: Bladder

REGIMEN: CISCA

CYCLOPHOSPHAMIDE [CTX] 650 mg/m2 IV...D1

DOXORUBICIN [DOX] 50 mg/m2 IV...D1
Caution: Monitor cumulative dose (cardiac toxicity)

CISPLATIN [CDDP] 100 mg/m2 IV...D2

CYCLE: 21-28 days
REFER: Sternberg JJ, et al: JAMA 1977; 238:2282-2287.

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DISEASE: Bladder

REGIMEN: CMV

CISPLATIN [CDDP] 100 mg/m2 IV/4hr...D2
at least 12 hours after MTX

METHOTREXATE [MTX] 30 mg/m2 IV...D1,8

VINBLASTINE [VLB] 4 mg/m2 IV...D1,8

CYCLE: 21 days
REFER: Harker WG, et al: J CLIN ONCOL 1985; 3:1463-1470.

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DISEASE: Bladder

REGIMEN: MITOMYCIN

MITOMYCIN C [MITC] 30 - 40 mg Intravesical...weekly
x 4-6 weeks then monthly x 6 months

CYCLE: none
REFER: Soloway MS: CANCER 1987; 60:502-513.

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DISEASE: Bladder

REGIMEN: MVAC

METHOTREXATE [MTX] 30 mg/m2 per day IV...D1,15,22

VINBLASTINE [VLB] 3 mg/m2 per day IV...D2,15,22

DOXORUBICIN [DOX] 30 mg/m2 IV...D2
Caution: Monitor cumulative dose (cardiac toxicity)

CISPLATIN [CDDP] 70 mg/m2 IV...D2

CYCLE: 28 days
REFER: Skeel RT: Handbook of Cancer Chemotherapy, 3rd Ed. Little, Brown & Co. 1991; 224-225.

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