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DISEASE: Acute Myelogenous

Select a REGIMEN:

A+D(7+3)(INDUCTION)
A+D+E(7+3+7)(INDUCTION)
HiDAC
IDA-AR 1 (INDUCTION)
IDA-AR 2 (CONSOLIDATION)
MC (INDUCTION)





DISEASE: Acute Myelogenous

REGIMEN: A+D(7+3)(INDUCTION)

    CYTARABINE [ARA-C] 100 mg/m2 per day x 7 CIV...D1-7

    DAUNORUBICIN [DNR] 45 mg/m2 per day IV...D1-3
    Caution: Monitor cumulative dose (cardiac toxicity) Note: Repeat for further induction or consolidation with cytarabine x 5 days and daunorubicin x 2 days

CYCLE: None
REFER: Dillman RO, et al: BLOOD 1991; 78:2520-2526.




DISEASE: Acute Myelogenous

REGIMEN: A+D+E(7+3+7)(INDUCTION)

    CYTARABINE [ARA-C] 100 mg/m2 per day CIV...D1-7

    DAUNORUBICIN [DNR] 50 mg/m2 per day IV...D1-3
    Caution: Monitor cumulative dose (cardiac toxicity)

    ETOPOSIDE [VP-16] 75 mg/m2 per day IV/1 hr...D1-7

CYCLE: Induction
REFER: Bishop J, et al: BLOOD 1990; 1/1 75(1):27-32.




DISEASE: Acute Myelogenous

REGIMEN: HiDAC

    CYTARABINE [ARA-C] 1.5 - 3 g/m2 IV/12 h
    x 4-6 days

CYCLE: None
REFER: Bloomfield CD, Herzig GP, eds.: HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA 1993; 7:47-79.




DISEASE: Acute Myelogenous

REGIMEN: IDA-AR 1 (INDUCTION)

    IDARUBICIN [IDA] 12 mg/m2 per day IV...D1-3
    Caution: Monitor cumulative dose (cardiac toxicity)

    CYTARABINE [ARA-C] 100 mg/m2 per day x 7 CIV...D1-7

CYCLE: None
REFER: Vogler WR, et al: J CLIN ONCOL 1992; 10:1103-1111.




DISEASE: Acute Myelogenous

REGIMEN: IDA-AR 2 (CONSOLIDATION)

    THIOGUANINE [6-TG] 100 mg/m2 PO q 12h
    x 10 doses

    CYTARABINE [ARA-C] 100 mg/m2 IV q 12h
    x 10 doses

    IDARUBICIN [IDA] 15 mg/m2 IV...D1
    Caution: Monitor cumulative dose (cardiac toxicity)

CYCLE: 21-28 days x 3 courses
REFER: Vogler WR, et al: J CLIN ONCOL 1992; 10:1103-1111.




DISEASE: Acute Myelogenous

REGIMEN: MC (INDUCTION)

    MITOXANTRONE [DHAD] 12 mg/m2 per day IV...D1-3
    Caution: Monitor cumulative dose (cardiac toxicity)

    CYTARABINE [ARA-C] 100 mg/m2 per day x 7 CIV...D1-7

CYCLE: Induction
REFER: Arlin Z, et al: LEUKEMIA 1990; 4:177-183.




Glaxo Wellcome

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