INTRODUCTION

DoseCalc OnLine is intended as a general reference only to supplement the existing knowledge of healthcare professionals. While the DoseCalc OnLine provides resources for quick access to referenced protocols, it should be recognized that many combination cancer regimens have variations.

DoseCalc OnLine does NOT provide criteria for selection of regimens or for assessment of the appropriateness of a regimen for a specific patient. DoseCalc ^® OnLine does NOT include information on potential side effects of specific regimens. In short, the DoseCalc OnLine is a limited database of information and a dosage calculator, and is NOT a substitute for the sound clinical judgement of the knowledgable health professional.

Health professionals using these regimens should consult complete prescribing information before using any drug included in a regimen. It should be noted that not all drugs and dosages listed in the regimens are necessarily approved by the Food and Drug Administration (FDA) for use in treating the specific cancer.

How to use the Regimens

Each disease category includes those regimens that are generally believed to be the most commonly used regimens for the specific disease. Each regimen includes a published reference. It should be noted, however, that not all drugs and dosages listed in the regimens are necessarily approved by the Food and Drug Administration (FDA) for use in treating the specific cancer.

Each listed regimen follows the following format:

1. Type of cancer
2. Protocol Acronym (eg: PAC)
3. Listing of drugs in the regimen
4. Abbreviations of drugs in regimen
5. Dosage schedule for each drug, usually expressed in units of per meter squared of patient body area (eg: mg/m2)

   mg = milligram

   kg = kilogram

   g = gram

   mL = mililiter

   MU = megaunits

6. Route of administration for each drug, expressed as:

   IV = IV infusion

   IVB = IV bolus

   CIV = Continous IV infusion

   IM = Intramuscular

   IT = Intrathecal

   PO = Oral

   SC = Subcutaneous

   IV (time) = IV infusion over specific time period

7. Dosing time, expressed as:

   H = hour

   D = day

   wk = week

   /1hr = over one hour

   x4 = for four times

   q6h = every 6 hours

   qd = every day

   Note:

   In reading days, a dash (-) means 'to'.

   eg: D1-4 is read 'day 1 to 4'

   In reading days, a comma (,) means 'and'

   eg: D1,5,12 is read 'days 1,5, and 12'

8. Cycles:

   Number and timing or recommended repetitions of therapy are usually expressed as number of days (eg: q28 days)

9. Reference:

   Citation for the protocol in abbreviated format

How to Use the Calculator

The reference information and calculations displayed by the DoseCalc software are fully editable so that the prescribing physician may adjust drug selection, dosages, or administration schedule for any regimen in the database.

UltiTech, Inc. and Glaxo Wellcome, Inc. specifically DISCLAIM AND EXCLUDE ALL EXPRESS OR IMPLIED WARRANTIES INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. THE PRESCRIBING PHYSICIAN IS SOLELY RESPONSIBLE FOR MAKING THE DECISION ON THERAPY, PRODUCT SELECTION, DOSE AND SCHEDULE.

DoseCalc is a registered trademark of Glaxo Wellcome Inc., Research Triangle Park, NC

©Copyright 1995, 1996, 1997 & 1998 Glaxo Wellcome, Inc.

Selling, distributing, publishing, circulating, or commercially exploiting this electronic database and software program without the express written permission of Glaxo Wellcome Inc. and UltiTech, Inc. is prohibited. Use of the database and software shall not convey any ownership right, title or interest, nor any security or other interest in any intellectual property rights relating to the database and software nor in any copy of any part of the database and software.

Medicine OnLine and UltiTech have no liability for content or goods on the Internet except as set forth in the Terms and Conditions of service. Please read the Disclaimer of Warranties before using information contained in this section. © Copyright 1995-2000 UltiTech, Inc. All Rights Reserved.